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Absence of mouse 2B4 promotes NK cell–mediated killing of activated CD8(+) T cells, leading to prolonged viral persistence and altered pathogenesis
Persistent viral infections are often associated with inefficient T cell responses and sustained high-level expression of inhibitory receptors, such as the NK cell receptor 2B4 (also known as CD244), on virus-specific T cells. However, the role of 2B4 in T cell dysfunction is undefined, and it is un...
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| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Clinical Investigation
2010
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2877945/ https://ncbi.nlm.nih.gov/pubmed/20440077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41264 |
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