IL-10 Suppression of NK/DC Crosstalk Leads to Poor Priming of MCMV-Specific CD4 T Cells and Prolonged MCMV Persistence

IL-10 is an anti-inflammatory cytokine that regulates the extent of host immunity to infection by exerting suppressive effects on different cell types. Herpes viruses induce IL-10 to modulate the virus-host balance towards their own benefit, resulting in prolonged virus persistence. To define the ce...

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Detalhes bibliográficos
Main Authors: Mandaric, Sanja, Walton, Senta M., Rülicke, Thomas, Richter, Kirsten, Girard-Madoux, Mathilde J. H., Clausen, Björn E., Zurunic, Antonija, Kamanaka, Masahito, Flavell, Richard A., Jonjic, Stipan, Oxenius, Annette
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410900/
https://ncbi.nlm.nih.gov/pubmed/22876184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002846
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