COMMD1 disrupts HIF-1α/β dimerization and inhibits human tumor cell invasion

The gene encoding COMM domain–containing 1 (COMMD1) is a prototypical member of the COMMD gene family that has been shown to inhibit both NF-κB– and HIF-mediated gene expression. NF-κB and HIF are transcription factors that have been shown to play a role in promoting tumor growth, survival, and inva...

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Autors principals: van de Sluis, Bart, Mao, Xicheng, Zhai, Yali, Groot, Arjan J., Vermeulen, Jeroen F., van der Wall, Elsken, van Diest, Paul J., Hofker, Marten H., Wijmenga, Cisca, Klomp, Leo W., Cho, Kathleen R., Fearon, Eric R., Vooijs, Marc, Burstein, Ezra
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877941/
https://ncbi.nlm.nih.gov/pubmed/20458141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40583
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