The unique hypusine modification of eIF5A promotes islet β cell inflammation and dysfunction in mice

In both type 1 and type 2 diabetes, pancreatic islet dysfunction results in part from cytokine-mediated inflammation. The ubiquitous eukaryotic translation initiation factor 5A (eIF5A), which is the only protein to contain the amino acid hypusine, contributes to the production of proinflammatory cyt...

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Hauptverfasser: Maier, Bernhard, Ogihara, Takeshi, Trace, Anthony P., Tersey, Sarah A., Robbins, Reiesha D., Chakrabarti, Swarup K., Nunemaker, Craig S., Stull, Natalie D., Taylor, Catherine A., Thompson, John E., Dondero, Richard S., Lewis, Eli C., Dinarello, Charles A., Nadler, Jerry L., Mirmira, Raghavendra G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2010
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877928/
https://ncbi.nlm.nih.gov/pubmed/20501948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38924
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