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Thermodynamics of RTA3 peptide binding to membranes and consequences for antimicrobial activity()

RTA3 is an α-helical, amphipathic peptide with broad-spectrum activity against Gram-negative bacteria and low mammalian cell toxicity. RTA3 contains a cysteine residue, replacement of which with an alanine or serine (RTA3-C15S) virtually abolishes antimicrobial activity. Much of the activity of RTA3...

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Detalhes bibliográficos
Main Authors: Hawrani, Ayman, Howe, Robin A., Walsh, Timothy R., Dempsey, Christopher E.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Pub. Co 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877818/
https://ncbi.nlm.nih.gov/pubmed/20346912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2010.03.017
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