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Hemolytic Activity of Membrane-Active Peptides Correlates with the Thermodynamics of Binding to POPC Bilayers

Understanding the mechanisms of antimicrobial, cytolytic and cell-penetrating peptides is important for the design of new peptides to be used as cargo-delivery systems or antimicrobials. But these peptides should not be hemolytic. Recently, we designed a series of such membrane-active peptides and t...

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Detalhes bibliográficos
Main Authors: Spaller, B. Logan, Trieu, Julie M., Almeida, Paulo F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584441/
https://ncbi.nlm.nih.gov/pubmed/23329339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00232-013-9525-z
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