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Transcription Inhibition by Platinum DNA Cross-links in Live Mammalian Cells

We have investigated the processing of site-specific Pt-DNA cross-links in live mammalian cells to enhance our understanding of the mechanism of action of platinum-based anticancer drugs. The activity of platinum drugs against cancer is mediated by a combination of processes including cell entry, dr...

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Main Authors: Ang, Wee Han, Myint, MyatNoeZin, Lippard, Stephen J.
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877768/
https://ncbi.nlm.nih.gov/pubmed/20443565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja101495v
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