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The Use of Orthologous Sequences to Predict the Impact of Amino Acid Substitutions on Protein Function
Computational predictions of the functional impact of genetic variation play a critical role in human genetics research. For nonsynonymous coding variants, most prediction algorithms make use of patterns of amino acid substitutions observed among homologous proteins at a given site. In particular, s...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2877731/ https://ncbi.nlm.nih.gov/pubmed/20523748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000968 |
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