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miR-22 Forms a Regulatory Loop in PTEN/AKT Pathway and Modulates Signaling Kinetics
BACKGROUND: The tumor suppressor PTEN (phosphatase and tensin homolog) is a lipid phosphatase that converts PIP3 into PIP2 and downregulates the kinase AKT and its proliferative and anti-apoptotic activities. The FoxO transcription factors are PTEN downstream effectors whose activity is negatively r...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2877705/ https://ncbi.nlm.nih.gov/pubmed/20523723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010859 |
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