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miR-22 forms a regulatory loop in PTEN/AKT pathway and modulates signaling kinetics.
The tumor suppressor PTEN (phosphatase and tensin homolog) is a lipid phosphatase that converts PIP3 into PIP2 and downregulates the kinase AKT and its proliferative and anti-apoptotic activities. The FoxO transcription factors are PTEN downstream effectors whose activity is negatively regulated by...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science (PLoS)
2010-05-01
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| Serie: | PLoS ONE |
| Accesso online: | http://europepmc.org/articles/PMC2877705?pdf=render |
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