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Constant pH replica exchange molecular dynamics in biomolecules using a discrete protonation model

A constant pH replica exchange molecular dynamics (REMD) method is proposed and implemented to improve coupled protonation and conformational state sampling. By mixing conformational sampling at constant pH (with discrete protonation states) with a temperature ladder, this method avoids conformation...

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Библиографические подробности
Главные авторы: Meng, Yilin, Roitberg, Adrian E.
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877402/
https://ncbi.nlm.nih.gov/pubmed/20514364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct900676b
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