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pH Replica-Exchange Method based on discrete protonation states

We propose a new algorithm for obtaining proton titration curves of ionizable residues. The algorithm is a pH replica-exchange method (PHREM) which is based on the constant pH algorithm of Mongan et al. [1]. In the original replica-exchange method, simulations of different replicas are performed at...

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Detalhes bibliográficos
Main Authors: Itoh, Satoru G., Damjanović, Ana, Brooks, Bernard R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3373023/
https://ncbi.nlm.nih.gov/pubmed/22002801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.23176
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