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Studies on the Site and Mode of TMPyP4 Interactions with Bcl-2 Promoter Sequence G-Quadruplexes

TMPyP4 (Mesotetra(N-methyl-4-pyridyl)porphine) is known to have a high affinity for G-quadruplex DNA. However, there is still some controversy over the exact site(s) and mode(s) of TMPyP4 binding to G-quadruplex DNA. We examined TMPyP4 interactions with seven G-quadruplex forming oligonucleotides. T...

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Detalhes bibliográficos
Main Authors: Nagesh, Narayana, Buscaglia, Robert, Dettler, Jamie M., Lewis, Edwin A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877325/
https://ncbi.nlm.nih.gov/pubmed/20513407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.02.050
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