β-Lapachone suppresses radiation-induced activation of nuclear factor-κB

Anticancer effects of β-lapachone (β-lap) are due to generation of ROS and metabolic catastrophes as a result of NAD(P)H:quinone oxidoreductase (NQO1)-mediated futile cycling between the oxidized and reduced forms of β-lap. It has been shown that NQO1 is also essential for the TNF-induced activation...

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Main Authors: Dong, Guang-Zhi, Oh, Eun-Taex, Lee, Hyemi, Park, Moon-Taek, Song, Chang Won, Park, Heon Joo
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Society for Biochemistry and Molecular Biology 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877251/
https://ncbi.nlm.nih.gov/pubmed/20200474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3858/emm.2010.42.5.034
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