β-Lapachone Significantly Increases the Effect of Ionizing Radiation to Cause Mitochondrial Apoptosis via JNK Activation in Cancer Cells

BACKGROUND: β-lapachone (β-lap), has been known to cause NQO1-dependnet death in cancer cells and sensitize cancer cells to ionizing radiation (IR). We investigated the mechanisms underlying the radiosensitization caused by β-lap. METHODOLOGY/PRINCIPAL FINDINGS: β-lap enhanced the effect of IR to ca...

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Auteurs principaux: Park, Moon-Taek, Song, Min-Jeong, Lee, Hyemi, Oh, Eun-Taex, Choi, Bo-Hwa, Jeong, Seong-Yun, Choi, Eun-Kyung, Park, Heon Joo
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188568/
https://ncbi.nlm.nih.gov/pubmed/21998736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025976
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