The anti-tumour compound, RH1, causes mitochondria-mediated apoptosis by activating c-Jun N-terminal kinase

BACKGROUND AND PURPOSE: 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1) is a bioreductive agent that is activated by the two-electron reductase NAD(P)H quinone oxidoreductase 1 (NQO1). Although the cytotoxic efficacy of RH1 against tumours has been studied extensively, the molecul...

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Detalhes bibliográficos
Main Authors: Park, Moon-Taek, Song, Min-Jeong, Oh, Eun-Taex, Lee, Hyemi, Choi, Bo-Hwa, Jeong, Seong-Yun, Choi, Eun-Kyung, Park, Heon Joo
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2011
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101619/
https://ncbi.nlm.nih.gov/pubmed/21250978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01233.x
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