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Regulation of natural killer T-cell development by deubiquitinase CYLD

Natural killer T (NKT) cells modulate immune responses against pathogens and tumours, as well as immunological tolerance. We show here that CYLD, a tumour suppressor with deubiquitinase function, has a pivotal and cell-intrinsic function in NKT cell development. Unlike other known NKT regulators, CY...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lee, Andrew J, Zhou, Xiaofei, Chang, Mikyoung, Hunzeker, John, Bonneau, Robert H, Zhou, Dapeng, Sun, Shao-Cong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876956/
https://ncbi.nlm.nih.gov/pubmed/20224552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.31
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