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Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage

Mutations in DJ-1 cause recessively transmitted early-onset Parkinson disease (PD), and oxidative damage to DJ-1 has been associated with the pathogenesis of late-onset sporadic PD. The precise biochemical function of DJ-1 remains elusive. Here, we report that DJ-1 is synthesized as a latent proteas...

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Detalhes bibliográficos
Main Authors: Chen, Jue, Li, Lian, Chin, Lih-Shen
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876885/
https://ncbi.nlm.nih.gov/pubmed/20304780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq113
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