The N-terminal Arg Residue Is Essential for Autocatalytic Activation of a Lipopolysaccharide-responsive Protease Zymogen

Factor C, a serine protease zymogen involved in innate immune responses in horseshoe crabs, is known to be autocatalytically activated on the surface of bacterial lipopolysaccharides, but the molecular mechanism of this activation remains unknown. In this study, we show that wild-type factor C expre...

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Detalhes bibliográficos
Main Authors: Kobayashi, Yuki, Shiga, Takafumi, Shibata, Toshio, Sako, Miyuki, Maenaka, Katsumi, Koshiba, Takumi, Mizumura, Hikaru, Oda, Toshio, Kawabata, Shun-ichiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162196/
https://ncbi.nlm.nih.gov/pubmed/25077965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.586933
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