An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist

BACKGROUND: Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T cells. We report a disorder caused by mutations of IL1RN, which encodes the interleukin-1–receptor antagonist, with prominent involvement of skin and bone. METHODS:...

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Main Authors: Aksentijevich, Ivona, Masters, Seth L., Ferguson, Polly J., Dancey, Paul, Frenkel, Joost, van Royen-Kerkhoff, Annet, Laxer, Ron, Tedgård, Ulf, Cowen, Edward W., Pham, Tuyet-Hang, Booty, Matthew, Estes, Jacob D., Sandler, Netanya G., Plass, Nicole, Stone, Deborah L., Turner, Maria L., Hill, Suvimol, Butman, John A., Schneider, Rayfel, Babyn, Paul, El-Shanti, Hatem I., Pope, Elena, Barron, Karyl, Bing, Xinyu, Laurence, Arian, Lee, Chyi-Chia R., Chapelle, Dawn, Clarke, Gillian I., Ohson, Kamal, Nicholson, Marc, Gadina, Massimo, Yang, Barbara, Korman, Benjamin D., Gregersen, Peter K., van Hagen, P. Martin, Hak, A. Elisabeth, Huizing, Marjan, Rahman, Proton, Douek, Daniel C., Remmers, Elaine F., Kastner, Daniel L., Goldbach-Mansky, Raphaela
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876877/
https://ncbi.nlm.nih.gov/pubmed/19494218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa0807865
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