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Ins(1,4,5)P(3) interacts with PIP(2) to regulate activation of TRPC6/C7 channels by diacylglycerol in native vascular myocytes

We investigated synergism between inositol 1,4,5-trisphosphate (Ins(1,4,5)P(3)) and diacylglycerol (DAG) on TRPC6-like channel activity in rabbit portal vein myocytes using single channel recording and immunoprecipitation techniques. Ins(1,4,5)P(3) at 10 μm increased 3-fold TRPC6-like activity induc...

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Bibliografske podrobnosti
Main Authors: Ju, Min, Shi, Jian, Saleh, Sohag N, Albert, Anthony P, Large, William A
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876800/
https://ncbi.nlm.nih.gov/pubmed/20211974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2009.185256
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