Different In Vivo Effects of HIV-1 Immunodominant Epitope-Specific Cytotoxic T Lymphocytes on Selection of Escape Mutant Viruses

HIV-1 escape mutants are well known to be selected by immune pressure via HIV-1-specific cytotoxic T lymphocytes (CTLs) and neutralizing antibodies. The ability of the CTLs to suppress HIV-1 replication is assumed to be associated with the selection of escape mutants from the CTLs. Therefore, we fir...

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Detalhes bibliográficos
Main Authors: Koizumi, Hirokazu, Hashimoto, Masao, Fujiwara, Mamoru, Murakoshi, Hayato, Chikata, Takayuki, Borghan, Mohamed Ali, Hachiya, Atsuko, Kawashima, Yuka, Takata, Hiroshi, Ueno, Takamasa, Oka, Shinichi, Takiguchi, Masafumi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876605/
https://ncbi.nlm.nih.gov/pubmed/20335254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02483-09
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