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A Five-Year Longitudinal Analysis of Sooty Mangabeys Naturally Infected with Simian Immunodeficiency Virus Reveals a Slow but Progressive Decline in CD4(+) T-Cell Count Whose Magnitude Is Not Predicted by Viral Load or Immune Activation

Natural simian immunodeficiency virus (SIV) infection in sooty mangabeys (SMs) typically does not result in AIDS, despite high-level viremia and significant depletion of mucosal CD4(+) T cells. Here, we report the results of the first longitudinal study of a large cohort of SMs naturally infected wi...

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Bibliografiske detaljer
Main Authors: Taaffe, Jessica, Chahroudi, Ann, Engram, Jessica, Sumpter, Beth, Meeker, Tracy, Ratcliffe, Sarah, Paiardini, Mirko, Else, James, Silvestri, Guido
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876601/
https://ncbi.nlm.nih.gov/pubmed/20335252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00039-10
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