Cleavage of Influenza Virus Hemagglutinin by Airway Proteases TMPRSS2 and HAT Differs in Subcellular Localization and Susceptibility to Protease Inhibitors

Proteolytic cleavage of the influenza virus surface glycoprotein hemagglutinin (HA) by host cell proteases is crucial for infectivity and virus spread. The proteases HAT (human airway trypsin-like protease) and TMPRSS2 (transmembrane protease serine S1 member 2) known to be present in the human airw...

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Main Authors: Böttcher-Friebertshäuser, Eva, Freuer, Catharina, Sielaff, Frank, Schmidt, Sarah, Eickmann, Markus, Uhlendorff, Jennifer, Steinmetzer, Torsten, Klenk, Hans-Dieter, Garten, Wolfgang
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876594/
https://ncbi.nlm.nih.gov/pubmed/20237084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00140-10
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