Cleavage of Influenza Virus Hemagglutinin by Airway Proteases TMPRSS2 and HAT Differs in Subcellular Localization and Susceptibility to Protease Inhibitors

Proteolytic cleavage of the influenza virus surface glycoprotein hemagglutinin (HA) by host cell proteases is crucial for infectivity and virus spread. The proteases HAT (human airway trypsin-like protease) and TMPRSS2 (transmembrane protease serine S1 member 2) known to be present in the human airw...

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Hlavní autoři: Böttcher-Friebertshäuser, Eva, Freuer, Catharina, Sielaff, Frank, Schmidt, Sarah, Eickmann, Markus, Uhlendorff, Jennifer, Steinmetzer, Torsten, Klenk, Hans-Dieter, Garten, Wolfgang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
Témata:
Virus-Cell Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876594/
https://ncbi.nlm.nih.gov/pubmed/20237084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00140-10
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