In Vitro and In Vivo Characterization of the Pseudomonas aeruginosa Cyclic AMP (cAMP) Phosphodiesterase CpdA, Required for cAMP Homeostasis and Virulence Factor Regulation

Cyclic AMP (cAMP) is an important second messenger signaling molecule that controls a wide variety of eukaryotic and prokaryotic responses to extracellular cues. For cAMP-dependent signaling pathways to be effective, the intracellular cAMP concentration is tightly controlled at the level of synthesi...

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Bibliographic Details
Main Authors: Fuchs, Erin L., Brutinel, Evan D., Klem, Erich R., Fehr, Anthony R., Yahr, Timothy L., Wolfgang, Matthew C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876501/
https://ncbi.nlm.nih.gov/pubmed/20348254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00168-10
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