The M230L Nonnucleoside Reverse Transcriptase Inhibitor Resistance Mutation in HIV-1 Reverse Transcriptase Impairs Enzymatic Function and Viral Replicative Capacity

The M230L mutation in HIV-1 reverse transcriptase (RT) is associated with resistance to first-generation nonnucleoside reverse transcriptase inhibitors (NNRTIs). The present study was designed to determine the effects of M230L on enzyme function, viral replication capacity (RC), and the extent to wh...

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Bibliographic Details
Main Authors: Xu, Hong-Tao, Quan, Yudong, Schader, Susan M., Oliveira, Maureen, Bar-Magen, Tamara, Wainberg, Mark A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876396/
https://ncbi.nlm.nih.gov/pubmed/20308384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01795-09
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