Regulation of microsomal prostaglandin E(2 )synthase-1 and 5-lipoxygenase-activating protein/5-lipoxygenase by 4-hydroxynonenal in human osteoarthritic chondrocytes

INTRODUCTION: This study aimed to investigate whether hydroxynonenal (HNE) depletion is responsible for the switch from cyclooxygenase-2 (COX-2) and microsomal prostaglandin E(2 )synthase-1 (mPGES-1) to 5-lipoxygenase-activating protein (FLAP) and 5-lipoxygenase (5-LOX). METHODS: For COX-2 and mPGES...

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Hlavní autoři: Chen, Shu-Huang, Fahmi, Hassan, Shi, Qin, Benderdour, Mohamed
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
Témata:
Research article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875653/
https://ncbi.nlm.nih.gov/pubmed/20144213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2926
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