Estrogen receptor alpha 46 is reduced in tamoxifen resistant breast cancer cells and re-expression inhibits cell proliferation and estrogen receptor alpha 66-regulated target gene transcription

Resistance to endocrine therapy is a major clinical problem in breast cancer. The role of ERα splice variants in endocrine resistance is largely unknown. We observed reduced protein expression of an N-terminally truncated ERα46 in endocrine- resistant LCC2, LCC9, and LY2 compared to MCF-7 breast can...

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Main Authors: Klinge, Carolyn M., Riggs, Krista A., Wickramasinghe, Nalinie S., Emberts, Celia G., McConda, David B., Barry, Parul N., Magnusen, Joan E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875375/
https://ncbi.nlm.nih.gov/pubmed/20302909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2010.03.013
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