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Estrogen receptor alpha 46 is reduced in tamoxifen resistant breast cancer cells and re-expression inhibits cell proliferation and estrogen receptor alpha 66-regulated target gene transcription
Resistance to endocrine therapy is a major clinical problem in breast cancer. The role of ERα splice variants in endocrine resistance is largely unknown. We observed reduced protein expression of an N-terminally truncated ERα46 in endocrine- resistant LCC2, LCC9, and LY2 compared to MCF-7 breast can...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2875375/ https://ncbi.nlm.nih.gov/pubmed/20302909 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2010.03.013 |
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