A Pilot Study to Evaluate the Safety and Efficacy of the Long-acting IL-1 Inhibitor, Rilonacept (IL-1 Trap) in Patients with Familial Cold Autoinflammatory Syndrome (FCAS)

OBJECTIVE: Familial cold autoinflammatory syndrome (FCAS) is caused by mutations in CIAS1 leading to excessive secretion of IL-1β, which is associated with cold induced fevers, joint pain and systemic inflammation. This pilot study was conducted to assess the safety and efficacy of the long acting I...

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Main Authors: Goldbach-Mansky, Raphaela, Shroff, Sharukh, Wilson, Mildred, Snyder, Christopher, Plehn, Sara, Barham, Beverly, Pham, Tuyet Hang, Kastner, Daniel L., Pucino, Frank, Wesley, Robert A., Papadopoulos, Joanne, Weinstein, Steven, Mellis, Scott
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875198/
https://ncbi.nlm.nih.gov/pubmed/18668591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.23620
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