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Arsenite suppresses Notch1 signaling in human keratinocytes

Arsenic is a well known human skin carcinogen whose mechanism of action remains to be elucidated. In this work using cultured human epidermal cells, arsenite suppressed accumulation of the transcriptionally active intracellular domain of Notch1. The cells responded to an active peptide from the Notc...

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Détails bibliographiques
Auteurs principaux: Reznikova, Tatiana V., Phillips, Marjorie A., Rice, Robert H.
Format: Artigo
Langue:Inglês
Publié: 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875141/
https://ncbi.nlm.nih.gov/pubmed/18633435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2008.207
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