A distal region of the human TGM1 promoter is required for expression in transgenic mice and cultured keratinocytes

BACKGROUND: TGM1(transglutaminase 1) is an enzyme that crosslinks the cornified envelope of mature keratinocytes. Appropriate expression of the TGM1 gene is crucial for proper keratinocyte function as inactivating mutations lead to the debilitating skin disease, lamellar ichthyosis. TGM1 is also exp...

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Библиографические подробности
Главные авторы: Phillips, Marjorie A, Jessen, Bart A, Lu, Ying, Qin, Qin, Stevens, Mary E, Rice, Robert H
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2004
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC416661/
https://ncbi.nlm.nih.gov/pubmed/15061870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-5945-4-2
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