Insertional mutagenesis in mice deficient for p15(Ink4b), p16(Ink4a), p21(Cip1), p27(Kip1) reveals cancer gene interactions and correlations with tumor phenotypes

The cyclin dependent kinase (CDK) inhibitors p15, p16, p21 and p27 are frequently deleted, silenced or downregulated in many malignancies. Inactivation of CDK inhibitors predisposes mice to tumor development demonstrating that these genes can act as tumor suppressors. Here we describe high-throughpu...

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Hlavní autoři: Kool, Jaap, Uren, Anthony G., Martins, Carla P., Sie, Daoud, de Ridder, Jeroen, Turner, Geoffrey, van Uitert, Miranda, Matentzoglu, Konstantin, Lagcher, Wendy, Krimpenfort, Paul, Gadiot, Jules, Pritchard, Colin, Lenz, Jack, Lund, Anders H., Jonkers, Jos, Rogers, Jane, Adams, David J., Wessels, Lodewyk, Berns, Anton, van Lohuizen, Maarten
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875110/
https://ncbi.nlm.nih.gov/pubmed/20068150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-2736
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