Insertional mutagenesis in mice deficient for p15(Ink4b), p16(Ink4a), p21(Cip1), p27(Kip1) reveals cancer gene interactions and correlations with tumor phenotypes

The cyclin dependent kinase (CDK) inhibitors p15, p16, p21 and p27 are frequently deleted, silenced or downregulated in many malignancies. Inactivation of CDK inhibitors predisposes mice to tumor development demonstrating that these genes can act as tumor suppressors. Here we describe high-throughpu...

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Detalhes bibliográficos
Main Authors: Kool, Jaap, Uren, Anthony G., Martins, Carla P., Sie, Daoud, de Ridder, Jeroen, Turner, Geoffrey, van Uitert, Miranda, Matentzoglu, Konstantin, Lagcher, Wendy, Krimpenfort, Paul, Gadiot, Jules, Pritchard, Colin, Lenz, Jack, Lund, Anders H., Jonkers, Jos, Rogers, Jane, Adams, David J., Wessels, Lodewyk, Berns, Anton, van Lohuizen, Maarten
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875110/
https://ncbi.nlm.nih.gov/pubmed/20068150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-2736
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