ARD1 Stabilization of TSC2 Suppresses Tumorigenesis Through the mTOR Signaling Pathway

Mammalian target of rapamycin (mTOR) regulates various cellular functions, including tumorigenesis, and is inhibited by the tuberous sclerosis 1 (TSC1)–TSC2 complex. Here, we demonstrate that arrest-defective protein 1 (ARD1) physically interacts with, acetylates, and stabilizes TSC2, thereby repres...

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Détails bibliographiques
Auteurs principaux: Kuo, Hsu-Ping, Lee, Dung-Fang, Chen, Chun-Te, Liu, Mo, Chou, Chao-Kai, Lee, Hong-Jen, Du, Yi, Xie, Xiaoming, Wei, Yongkun, Xia, Weiya, Weihua, Zhang, Yang, Jer-Yen, Yen, Chia-Jui, Huang, Tzu-Hsuan, Tan, Minjia, Xing, Gang, Zhao, Yingming, Lin, Chien-Hsing, Tsai, Shih-Feng, Fidler, Isaiah J., Hung, Mien-Chie
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874891/
https://ncbi.nlm.nih.gov/pubmed/20145209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000590
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