Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor

BACKGROUND AND PURPOSE: Cysteinyl leukotrienes (CysLTs) have been implicated in the pathophysiology of inflammatory and cardiovascular disorders. Their actions are mediated by CysLT(1) and CysLT(2) receptors. Here we report the discovery of 3-({[(1S,3S)-3-carboxycyclohexyl]amino}carbonyl)-4-(3-{4-[4...

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Autores principales: Wunder, F, Tinel, H, Kast, R, Geerts, A, Becker, EM, Kolkhof, P, Hütter, J, Ergüden, J, Härter, M
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2010
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874861/
https://ncbi.nlm.nih.gov/pubmed/20423349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00730.x
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