Methylenedioxymethamphetamine inhibits mitochondrial complex I activity in mice: a possible mechanism underlying neurotoxicity

BACKGROUND AND PURPOSE: 3,4-methylenedioxymethamphetamine (MDMA) causes a persistent loss of dopaminergic cell bodies in the substantia nigra of mice. Current evidence indicates that such neurotoxicity is due to oxidative stress but the source of free radicals remains unknown. Inhibition of mitochon...

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Bibliografische gegevens
Hoofdauteurs: Puerta, Elena, Hervias, Isabel, Goñi-Allo, Beatriz, Zhang, Steven F, Jordán, Joaquín, Starkov, Anatoly A, Aguirre, Norberto
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Blackwell Publishing Ltd 2010
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Research Papers with Commentaries
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874846/
https://ncbi.nlm.nih.gov/pubmed/20423338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00663.x
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