Methylenedioxymethamphetamine inhibits mitochondrial complex I activity in mice: a possible mechanism underlying neurotoxicity

BACKGROUND AND PURPOSE: 3,4-methylenedioxymethamphetamine (MDMA) causes a persistent loss of dopaminergic cell bodies in the substantia nigra of mice. Current evidence indicates that such neurotoxicity is due to oxidative stress but the source of free radicals remains unknown. Inhibition of mitochon...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Puerta, Elena, Hervias, Isabel, Goñi-Allo, Beatriz, Zhang, Steven F, Jordán, Joaquín, Starkov, Anatoly A, Aguirre, Norberto
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 2010
Sujets:
Research Papers with Commentaries
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874846/
https://ncbi.nlm.nih.gov/pubmed/20423338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00663.x
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