Methylenedioxymethamphetamine inhibits mitochondrial complex I activity in mice: a possible mechanism underlying neurotoxicity

BACKGROUND AND PURPOSE: 3,4-methylenedioxymethamphetamine (MDMA) causes a persistent loss of dopaminergic cell bodies in the substantia nigra of mice. Current evidence indicates that such neurotoxicity is due to oxidative stress but the source of free radicals remains unknown. Inhibition of mitochon...

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Autors principals: Puerta, Elena, Hervias, Isabel, Goñi-Allo, Beatriz, Zhang, Steven F, Jordán, Joaquín, Starkov, Anatoly A, Aguirre, Norberto
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2010
Matèries:
Research Papers with Commentaries
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874846/
https://ncbi.nlm.nih.gov/pubmed/20423338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00663.x
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