Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression

OBJECTIVE: Regulatory T-cells (Tregs) recognizing islet autoantigens are proposed as a key mechanism in the maintenance of self-tolerance and protection from type 1 diabetes. To date, however, detailed information on such cells in humans, and insight into their mechanisms of action, has been lacking...

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Bibliographic Details
Main Authors: Tree, Timothy I.M., Lawson, Jennifer, Edwards, Hannah, Skowera, Ania, Arif, Sefina, Roep, Bart O., Peakman, Mark
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2010
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874706/
https://ncbi.nlm.nih.gov/pubmed/20299476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0503
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