Glycerol-3-Phosphate Acyltransferase 1 Deficiency in ob/ob Mice Diminishes Hepatic Steatosis but Does Not Protect Against Insulin Resistance or Obesity

OBJECTIVE: Hepatic steatosis is strongly associated with insulin resistance, but a causal role has not been established. In ob/ob mice, sterol regulatory element binding protein 1 (SREBP1) mediates the induction of steatosis by upregulating target genes, including glycerol-3-phosphate acyltransferas...

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Bibliografiske detaljer
Main Authors: Wendel, Angela A., Li, Lei O., Li, Yue, Cline, Gary W., Shulman, Gerald I., Coleman, Rosalind A.
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2010
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874692/
https://ncbi.nlm.nih.gov/pubmed/20200319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1380
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