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Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells
In Saccharomyces cerevisiae, chemical or genetic inhibition of proteasome activity induces new proteasome synthesis promoted by the transcription factor RPN4. This ensures that proteasome activity is matched to demand. This transcriptional feedback loop is conserved in mammals, but its molecular bas...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2874685/ https://ncbi.nlm.nih.gov/pubmed/20385086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.02.029 |
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