Chargement en cours...
PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells
Memory B and plasma cells (PCs) are generated in the germinal center (GC). As PD-1 is highly expressed in T follicular helper cells (T(FH)), we investigated the role of PD-1 signaling in the humoral response. We found that PD-L1 and PD-L2 are upregulated on GC B cells. Pdcd1lg2(−/−), CD274(−/−)Pdcd1...
Enregistré dans:
| Auteurs principaux: | , , , , , |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2874069/ https://ncbi.nlm.nih.gov/pubmed/20453843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1877 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|