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PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells
Memory B and plasma cells (PCs) are generated in the germinal center (GC). As PD-1 is highly expressed in T follicular helper cells (T(FH)), we investigated the role of PD-1 signaling in the humoral response. We found that PD-L1 and PD-L2 are upregulated on GC B cells. Pdcd1lg2(−/−), CD274(−/−)Pdcd1...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2874069/ https://ncbi.nlm.nih.gov/pubmed/20453843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1877 |
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