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Functional Significance May Underlie the Taxonomic Utility of Single Amino Acid Substitutions in Conserved Proteins

We hypothesized that some amino acid substitutions in conserved proteins that are strongly fixed by critical functional roles would show lineage-specific distributions. As an example of an archetypal conserved eukaryotic protein we considered the active site of β-tubulin. Our analysis identified one...

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Autores principales: Tyler, Kevin M., Wagner, Gerd K., Wu, Qiong, Huber, Katharina T.
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer-Verlag 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874023/
https://ncbi.nlm.nih.gov/pubmed/20386893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00239-010-9338-y
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