Toll-Like Receptor 4 Promoter Polymorphisms: Common TLR4 Variants May Protect against Severe Urinary Tract Infection

BACKGROUND: Polymorphisms affecting Toll-like receptor (TLR) structure appear to be rare, as would be expected due to their essential coordinator role in innate immunity. Here, we assess variation in TLR4 expression, rather than structure, as a mechanism to diversify innate immune responses. METHODO...

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Main Authors: Ragnarsdóttir, Bryndís, Jönsson, Klas, Urbano, Alexander, Grönberg-Hernandez, Jenny, Lutay, Nataliya, Tammi, Martti, Gustafsson, Mattias, Lundstedt, Ann-Charlotte, Leijonhufvud, Irene, Karpman, Diana, Wullt, Björn, Truedsson, Lennart, Jodal, Ulf, Andersson, Björn, Svanborg, Catharina
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2010
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873976/
https://ncbi.nlm.nih.gov/pubmed/20505764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010734
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