Toll-Like Receptor 4 Promoter Polymorphisms: Common TLR4 Variants May Protect against Severe Urinary Tract Infection

BACKGROUND: Polymorphisms affecting Toll-like receptor (TLR) structure appear to be rare, as would be expected due to their essential coordinator role in innate immunity. Here, we assess variation in TLR4 expression, rather than structure, as a mechanism to diversify innate immune responses. METHODO...

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Detalhes bibliográficos
Main Authors: Ragnarsdóttir, Bryndís, Jönsson, Klas, Urbano, Alexander, Grönberg-Hernandez, Jenny, Lutay, Nataliya, Tammi, Martti, Gustafsson, Mattias, Lundstedt, Ann-Charlotte, Leijonhufvud, Irene, Karpman, Diana, Wullt, Björn, Truedsson, Lennart, Jodal, Ulf, Andersson, Björn, Svanborg, Catharina
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873976/
https://ncbi.nlm.nih.gov/pubmed/20505764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010734
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