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Toll-Like Receptor 4 Promoter Polymorphisms: Common TLR4 Variants May Protect against Severe Urinary Tract Infection

BACKGROUND: Polymorphisms affecting Toll-like receptor (TLR) structure appear to be rare, as would be expected due to their essential coordinator role in innate immunity. Here, we assess variation in TLR4 expression, rather than structure, as a mechanism to diversify innate immune responses. METHODO...

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Bibliografiske detaljer
Main Authors: Ragnarsdóttir, Bryndís, Jönsson, Klas, Urbano, Alexander, Grönberg-Hernandez, Jenny, Lutay, Nataliya, Tammi, Martti, Gustafsson, Mattias, Lundstedt, Ann-Charlotte, Leijonhufvud, Irene, Karpman, Diana, Wullt, Björn, Truedsson, Lennart, Jodal, Ulf, Andersson, Björn, Svanborg, Catharina
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873976/
https://ncbi.nlm.nih.gov/pubmed/20505764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010734
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