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Optimization algorithms for functional deimmunization of therapeutic proteins
BACKGROUND: To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the response is the recognition and surface display by antigen-presenting cells of epitopes, short peptide fragments derived...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
BioMed Central
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2873530/ https://ncbi.nlm.nih.gov/pubmed/20380721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-11-180 |
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