Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.

Herpes simplex virus infection of mammalian hosts involves lytic replication at a primary site, such as the cornea, translocation by axonal transport to sensory ganglia and replication, and latent infection at a secondary site, ganglionic neurons. The virus-encoded thymidine kinase, which is a targe...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Coen, D M, Kosz-Vnenchak, M, Jacobson, J G, Leib, D A, Bogard, C L, Schaffer, P A, Tyler, K L, Knipe, D M
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1989
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC287348/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2543985/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.12.4736
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