Signal pathways JNK and NF-κB, identified by global gene expression profiling, are involved in regulation of TNFα-induced mPGES-1 and COX-2 expression in gingival fibroblasts

BACKGROUND: Prostaglandin E(2 )(PGE(2)) is involved in several chronic inflammatory diseases including periodontitis, which causes loss of the gingival tissue and alveolar bone supporting the teeth. We have previously shown that tumor necrosis factor α (TNFα) induces PGE(2 )synthesis in gingival fib...

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Hlavní autoři: Båge, Tove, Lindberg, Johan, Lundeberg, Joakim, Modéer, Thomas, Yucel-Lindberg, Tülay
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873473/
https://ncbi.nlm.nih.gov/pubmed/20398340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-11-241
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