Cadmium induces Wnt signaling to upregulate proliferation and survival genes in sub-confluent kidney proximal tubule cells

BACKGROUND: The class 1 carcinogen cadmium (Cd(2+)) disrupts the E-cadherin/β-catenin complex of epithelial adherens junctions (AJs) and causes renal cancer. Deregulation of E-cadherin adhesion and changes in Wnt/β-catenin signaling are known to contribute to carcinogenesis. RESULTS: We investigated...

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Main Authors: Chakraborty, Prabir K, Lee, Wing-Kee, Molitor, Malte, Wolff, Natascha A, Thévenod, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873433/
https://ncbi.nlm.nih.gov/pubmed/20459685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-102
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