Deficiency of the dual ubiquitin/SUMO ligase Topors results in genetic instability and an increased rate of malignancy in mice

BACKGROUND: Topors is a nuclear protein that co-localizes with promyelocytic leukemia bodies and has both ubiquitin and SUMO E3 ligase activity. Expression studies implicated Topors as a tumor suppressor in various malignancies. To gain insight into the function of Topors, we generated a Topors-defi...

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Bibliographic Details
Main Authors: Marshall, Henderson, Bhaumik, Mantu, Aviv, Hana, Moore, Dirk, Yao, Ming, Dutta, Jayeeta, Rahim, Hussein, Gounder, Murugesan, Ganesan, Shridar, Saleem, Ahamed, Rubin, Eric
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
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Research article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873312/
https://ncbi.nlm.nih.gov/pubmed/20429939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-11-31
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