A Comparative Evaluation of the Dopamine D(2/3) Agonist Radiotracer [(11)C](−)-N-Propyl-norapomorphine and Antagonist [(11)C]Raclopride to Measure Amphetamine-Induced Dopamine Release in the Human Striatum

(−)-N-Propyl-norapomorphine (NPA) is a full dopamine D(2/3) receptor agonist, and [(11)C]NPA is a suitable radiotracer to image D(2/3) receptors configured in a state of high affinity for agonists with positron emission tomography (PET). In this study, the vulnerability of the in vivo binding of [(1...

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Autors principals: Narendran, Rajesh, Mason, N. Scott, Laymon, Charles M., Lopresti, Brian J., Velasquez, Natalie D., May, Maureen A., Kendro, Steve, Martinez, Diana, Mathis, Chester A., Frankle, W. Gordon
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2010
Matèries:
Neuropharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872952/
https://ncbi.nlm.nih.gov/pubmed/20103586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.163501
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