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Cytochrome P450 1A2 Detoxicates Aristolochic Acid in the Mouse
Aristolochic acids (AAs) are plant-derived nephrotoxins and carcinogens responsible for chronic renal failure and associated urothelial cell cancers in several clinical syndromes known collectively as aristolochic acid nephropathy (AAN). Mice provide a useful model for study of AAN because the renal...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2872943/ https://ncbi.nlm.nih.gov/pubmed/20164109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.032201 |
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